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Action potential is a phenomenon in which the membrane potential in a cell is first increased but then decreases. It is a characteristic feature of a number of animal cells including muscles cells, neurons and cell types that are endocrine. Certain plant cells also produce them. Neurons play an essential part in cell-to cell communication. The beta cells of the pancreas action potentials are associated with the release of insulin. Plasma membranes contain a distinct type of voltage-gated Ion channels creating action potential. These channels are shut as long as the potential of the membrane is near its resting capacity of cells, however when the membrane's voltage increases it becomes active. Once the channels are open, they allow the flow of sodium ions which increases the cell's membrane potency. The rapid inward flow of sodium ions result in changing the membrane's polarity and consequently they disappear. The potassium channels after that are activated , and you can see an outward movement of sodium ions. Due to this, the membrane returns back to its normal state. A temporary negative shift, known as refractory time prevents the back motion of the potential. In the animal cell, generally two kinds of these voltages are identified, for instance, one which is triggered via voltage-gated channels, the other can be produced by voltage-gated calcium channels.

Nearly all cells keep an electrical difference between the outside and inside. The cell's voltage is measured in milli volts (mV). The voltage of a typical animal cell is -70mV. In majority of cells very minimal voltage fluctuations have been observed for their existence, but in some cells this is a usual feature. Some cells also show up and down cycles as the voltage goes up and down. The duration of these potentials fluctuate over a large range. In brain cells the up and down cycle of action potential are completed in less than thousandth of a second while in other cells, these cycle may last for several seconds. The electrical characteristic of a cell in the animal kingdom is dependent on the membrane structure. Cell membrane is comprised of an outer layer of lipids as well as proteins. The lipid layer serves as an insulation.

All animal cells are electrically polarized as they maintain a voltage variation known as membrane potential. In case of neurons, , dendrites and cell bodies have different electrical properties. The area that is most excitable in an neuron is its axon hillock. However, the axon and body too can be stimulated. At the axon hillock the threshold potential for resting is -70mV and the threshold potential is -55 mgV. The synaptic inputs to the neurons cause depolarization, causing the membrane potential to increase or fall. A potential for action is created when enough depolarization is accumulated and the membrane current reaches the threshold.

The action potential results in the function of voltage-gated channels that are found in the plasma membrane of a cell. A voltage-gated Ion Channel is actually a cluster composed of proteins that remain within the plasma membrane. They produce an action potential in order to create positive feedback loop. Membrane current is responsible monitoring the status of these channels. Action potential is generated when the positive feedback cycle runs at full speed. The duration as well as the magnitude are dependent on the bio-physical properties of the voltage-gated Ion Channels. A variety of Ion Channels are available that are believed to generate positive feedback cycles and ultimately cause the creation of these potentials. Voltage-gated sodium channels play a role in the creation of more powerful impulses like nerve impulse. They are slower than those that occur by muscle cells are controlled by the calcium ion channels.The most studied voltage-gated Ion channels are sodium ion channels involved in higher speed nerve impulse transmission.

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