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Nearly all cells keep some degree of voltage variation between their environment and their inside. The voltage of a cell is measured in milli volts (mV). The typical voltage for an animal cell is about -70 mV. The majority of cells show tiny voltage fluctuations are observed to occur , however in certain cells this is a regular characteristic. Some cells also display variations in the voltage, as they increase and decrease in voltage. The duration of these potentials vary throughout a vast range. In brain cells the down and up motion potential cycle are complete in less than the thousandth of a second. However, in other types of cells the sequences can take as long as a couple of seconds. The electrical ability of an animal cell is dependent on the membrane structure. Cell membrane is made up of layers of lipids, and proteins. The lipid layer acts as an insulation.
All animal cells are electrically polarized due to a voltage difference called membrane potential. In case of cells, neurons and axons, dendrites and the cell body all have different electrical properties. The most excitable component of a neuron is the axon hillock, but the axon and the cell body too can be stimulated. At the axon hillock the resting potential is 70 mV and the threshold potential is at -55 mV. Synaptic inputs into the neuron lead to depolarization. This causes the membrane potential to increase or decrease. The action potential is generated when enough depolarization happens and the membrane potential crosses the threshold.
Action potential is the result of activity of voltage-gated ion channels which are located within the plasma membranes of cells. A voltage-gated , ion channel is actually a cluster made of proteins. They remain in the plasma membrane. It generates movement potential because it is able to give rise to an positive feedback loop. Membrane potential plays a role in maintaining the state of the ion channels. The action potential is created during the time that the feedback cycle takes place at full intensity. The frequency and duration are controlled by the bio-physical characteristics of the ion channels that are voltage-gated. Ion channels of various types exist that can generate positive feedback cycles , which eventually lead to the generation of these potentials. Voltage-gated sodium channels play a role in the generation of larger potentials , similar to those that result from nerve impulse. More slow ones such as those produced in muscle cells are controlled by calcium ion channels.The ones that have been the most extensively studied voltage -gated Ion channels are sodium channels, which play a role in the faster conduction of nerve impulses.
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