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Action potential is an event where the membrane potential in a cell is first increased then decreases. It is the characteristic property that is present in a wide variety of animal cells namely, muscles cells, neurons and endocrin cells. Some plant cells also make them. Neurons play an important role in cell-tocell communications. in pancreas beta cell action potential is linked to hormone release. Plasma membrane is a type of voltage-gated ion channel for creating action potential. They remain closed once the membrane's voltage is within what is the limit of the cell but when the membrane's voltage increases and the channels begin to open, they become active. The channels that are active allow for an inward flow sodium ions. This can increase your membrane's potential. The swift inward flow of sodium ions alters the membrane's polarity which causes them to are inactive. The potassium channels, after which, become activated and then there's an outward flowing of sodium ions. Due to this, the membrane is returned to its original state. A transient , negative shift known as refractory duration prevents the reverse running of the action kinetic. In animal cells generally two varieties of these possibles are in existence, one that is generated by the voltage-gated calcium channels, while the other results from calcium channels that are voltage-gated.

Most cells have an electrical difference between their environment and their inside. The cell's voltage is measured in milli volts (mV). The voltage of a typical animal cell is -70 mV. In most cells, tiny voltage fluctuations are observed for their existence, but in some cells this is an expected feature. Cells can show the cycle of up and down as the voltage goes up and down. The time between these potentials can vary widely. In brain cells, the up and down process of action possible are completed in less that a thousandth of a second. However, in other cells, the cycles may take several seconds. The electrical characteristic of a cell in the animal kingdom is dependent upon the membrane structure. Cell membrane is comprised of layers of lipids, and proteins. The lipid layer functions as an insulation.

All animal cells are electrically polarized , as they sustain a voltage variation called membrane potential. For neurons, dendrites, axons as well as the cell body have various electrical properties. Most excitable portion of neurons is the axon hillock but axon and cell body are also excited. At the axon hillock the resting potential is -70mV and the threshold is 55 millivolts. Synaptic stimulation to the neuron induce depolarization and cause the membrane potential to rise or decrease. The action potential is generated when enough depolarization develops until the membrane potential reaches a threshold value.

Action potential is the outcome of activity of voltage-gated ion channels which are located within the plasma membrane of cells. A voltage-gated Ion Channel is actually a cluster composed of proteins that remain inside the plasma membrane. These proteins produce an action potential since it could produce the positive feedback loop. Membrane potential plays a role in setting the parameters of these channels. The action potential is created in the event that the positive feedback process takes place at full intensity. The time and amplitude are determined by the bio-physical properties of the voltage-gated Ion Channels. Several types of ion channels exist that can generate positive feedback mechanisms and lead to the generation of these potentials. Voltage-gated sodium channels play a role in the production of high-speed potentials similar to those generated by nerve impulse. Lesser ones, such as those created in muscles are controlled by calcium Ion channels.The most researched voltage-gated Ion channels are the sodium ion channels involved in quicker nerve impulse conduction.

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