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Action potential is an event where the membrane potential in a cell is first increased and then decreases. It is a common characteristic for a range of human cells, which include muscles, neurons and the endocrine cell. Some plant cells also produce these. Neurons play a crucial role in cell-to-cell communication. in pancreas beta cell action potentials are linked with production of insulin. Plasma membrane is a type of voltage-gated channels for producing action potential. The channels remain closed when the membrane potential is within it's resting value of the cell but when the membrane potential rises then the channels will become active. When the channels are inactive, they permit the inward flow of sodium ions that increase its membrane potential. The rapid inward flow sodium ions result in changing the membrane's polarity and consequently they turn off. After this, potassium channels get activated and that is followed by an outward flow of potassium ions . Upon this, the membrane is returned to its neutral state. A transient negative shift , also known as refractory duration prevents the reverse moving of the action-potential. In animal cells typically two types of potentials are known for example, one due to voltage-gated sodium channels and the other which can be produced by voltage-gated calcium channels.

The majority of cells have an electrical difference between their interior and exterior environment. The voltage of the cell is measured in millivolts (mV). The typical voltage of an animal cell is about -70 mV. In the majority of cells tiny voltage fluctuations are observed to be present, however in some cells, this is a standard characteristic. Some cells show fluctuations in voltage as the voltage drops and increases. The duration of these voltages differ across a broad range. In brain cells the up and down cycle of action potential are completed in less than a thousandth of a second while in other cell types, the intervals may be prolonged to several seconds. The electrical activity of an animal cell is influenced by the membrane structure. Cell membrane is made up of an outer layer of lipids as well as proteins. The lipid layer functions as an insulation.

Animal cells are all electro-polarized. They keep a voltage variation known as membrane potential. For neurons, dendrites, axons as well as the cell body have various electrical characteristics. Most excitable portion of neuron is called the axon hillock however axons and the cell body can also be stimulated. At the axon , the resting potential is -70 mV and the threshold potential is 55 millivolts. Synaptic connections to the nerve result in depolarization that causes the membrane potential to increase or decrease. The action potential is generated when sufficient depolarization takes place and the membrane potential exceeds a threshold value.

The action potential results in the function of voltage-gated channels which are located within the plasma membrane of cells. A voltage-gated Ion Channel is actually a group of proteins that remain embedded within the plasma membrane. They produce action potential because it can generate positive feedback loop. Membrane potential is responsible for managing the state of Ion channels. The action potential is created when the feedback cycle goes on at full-speed. The time and the intensity are controlled by the bio-physical characteristics of the ion channels that are voltage-gated. Several types of ion channels are available that are believed to generate positive feedback cycles , which eventually create these potentials. Voltage-gated sodium channels play a role in the creation of fast potentials , similar to those that result from nerve impulse. In contrast, the slower ones produced in the muscles are controlled by calcium Ion channels.The most intensively studied voltage-gated channel are sodium ion channels which are involved in quicker nerve impulse conduction.

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