Ozzy Osbourne Action Figure
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In most cells, there is some degree of voltage variation between their internal and external environments. The voltage of a cell is measured in millivolts (mV). The typical voltage for an animal cell is -70 mV. In most cells, small voltage fluctuations are reported to occur but in some cells this may be a common feature. Some cells exhibit an up-and-down cycle as the voltage decreases and increases. The time between these potentials can be varied over a broad spectrum. In brain cells the down and up cycle of the action potential is completed in a fraction of a millisecond of a second while in other cells, these processes can last several seconds. The electrical function of an animal cell is dependent upon the membrane structure. Cell membrane is comprised of one layer of lipids along with proteins. The lipid layer acts as an insulation.
All animal cells are electrically polarized as they maintain the same voltage, also known as membrane potential. For neurons, axons, dendrites and the body of the cell have distinct electrical characteristics. The most excitable component of a neuron is the axon hillock, however, axons as well as cells body too can be stimulated. At the axon hillock the resting potential is -70mV and the threshold voltage is 55 mgV. Synaptic connections to the nerve induce depolarization and cause the membrane potential to rise or decrease. Action potentials are produced when enough depolarization has occurred and the membrane current reaches a threshold value.
Action potential is the result of the work of voltage-gated Ion channels located in the plasma membrane of a cell. The voltage-gated ion channel actually a cluster of proteins that remain embedded in plasma membrane and produces an action potential in order to create the positive feedback loop. Membrane potential is accountable for controlling the condition of these channels. The action potential is created during the time that the feedback cycle takes place at full intensity. The duration as well as the magnitude are determined by the biophysical properties of the voltage-gated Ion Channels. Many types of ion channels have been identified which generate positive feedback processes that produce these potentials. Voltage-gated sodium-channels are involved with the creation of higher potentials like those of nerve impulse. Slower ones like those produced by muscles cells are controlled by the calcium ion channels.The most extensively studied voltage-gated channel are sodium ion channels involved in the speedier nerve impulse conduction.
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